STUDIES ON DEGRADATION OF ANTIGENICITY OF PPR VACCINE AND ASSESSMENT OF ITS MATERNAL ANTIBODY. Sayam ASM, Rahman MB, Islam MR, Ramam MM, Hoque N

ABSTRACT

The degradation procedure of antigenecity of PPR vaccine after reconstitution was studied in goats at farmers’ level with seven groups of animals and each group had four animals at Isagram, Mymensingh, the mean antibody titre±SD calculated with CELISA of sera samples collected at pre-vaccination, at 14th and 28th day of post vaccination were 36.92%, 23.37%, 24.33%, 34.23%, 23.56%, 30.69%, 15.42%; 60.91%, 59.47%, 58.97%, 57.05%, 55.16%, 41.01%, 36.69% and 72.77%, 71.37%, 69.74%, 60.24%, 55.41%, 46.12%, 35.31% in respective to 0, 0.5, 1, 1.5, 2, 2.5, and 3 hours interval. Similarly, at Myzebari, Mymensingh, the mean antibody titre±SD at pre vaccination, 14th and 28th day of post vaccination were 26.90%, 24.99%, 26.33%, 17.73%, 30.57%, 28.03%, 24.99%; 61.17%, 58.41%, 57.94%, 49.29%, 51.48%, 34.01%, 57.94%, 49.29%, 51.48%, 34.01%, 28.88% and 72.36%, 65.08%, 63.85%, 57.85%, 54.29%, 42.84%, 24.50% in respective to 0, 0.5, 1, 1.5, 2, 2.5 and 3 hours interval. Both the trail shows antigenicity degrades gradually with time after reconstitution of vaccine which may be due to the exposure of vaccine to temperature, light and reconstituent (PBS). On the other hand, assessment of maternal antibody was done collecting sera samples from kids and their respective dams from Government goat farm and BLRI goat farm Savar, Dhaka. All the dams had been vaccinated every 6 months for the past two years. At Government goat farm the kids were divided into 5 age groups, 10-30 days, 31-60 days, 61-90 days, 91-120 days and 121-160 days. The mean antibody titre±SD estimated with C-ELISA of respective age groups of kids and respective dams at Government goat farm, Savar were 54.69%, 53.99%, 52.86%, 52.73%, 40.17%, and 67.58%, 63.73%, 66.71, 66.69%, 59.02%. At BLRI farm the kids were divided into 3 age groups 10-30 days, 31-60 days, and 61-90 days. The mean antibody titre±SD of kids in these groups were 54.09%, 50.93%, 50.15% and respective dams were 66.66%, 63.59%, 66.51%. From the above study it could be concluded that up to 4 months of age of kids of the vaccinated dams, the maternal antibody remains above 50%. So kids should be vaccinated after 4 months of age.

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